Seybold Report ISSN: 1533-9211
Sunit Ramesh Kulkarni, Dr. Satyavir Singh
Vol 18, No 11 ( 2023 ) | Licensing: CC 4.0 | Pg no: 488-492 | Published on: 30-11-2023
Abstract
Ruthenium-catalyzed C-H activation has been investigated as an efficient methodology for the synthesis of pyridine heterocycles in a single step. This study utilized the redox-neutral reagent hydroxylamine-O-sulfonic acid (HOSA) to facilitate the reaction. Various solvents were screened to optimize the reaction conditions, leading to a significant enhancement in the yield and selectivity of the desired pyridine products. The findings demonstrated that the choice of solvent played a crucial role in the efficiency of the catalytic process. This approach offers a streamlined and sustainable route for the synthesis of pyridine heterocycles, highlighting the potential of ruthenium catalysis in heterocycle formation.
Keywords:
Ruthenium catalysis, C-H activation, pyridine synthesis, hydroxylamine-O-sulfonic acid (HOSA), solvent screening, redox-neutral reagent, heterocycle formation.