Seybold Report ISSN: 1533-9211
Vetriselvi Subramaniyan1, Anitha Akilan2, K. Revathi2, Senthilkumari 3, Jayanthi 4, Suresh Dhanaraj* 1Department of Microbiology, School of Life Sciences, Vels Institute of Science, Technology, and Advanced Studies (VISTAS), Pallavaram, Chennai, 600 117 Tamil Nadu, India. 2 Professor and Former Director of Research, Meenakshi Academy of Higher Education and Research, Chennai – 600078, Tamil Nadu, India. 2 Meenakshi Academy of Higher Education and Research, Chennai – 600078, Tamil Nadu, India. 3 Assistant professor; Head of department of zoology, Chellammal College, Chennai. 4 Department of zoology Arignar Anna govt.arts college for women walajapet - 632 513
Vol 17, No 10 ( 2022 ) | DOI: 10.5281/zenodo.7221731 | Licensing: CC 4.0 | Pg no:1871-1880 | Published on: 18-10-2022
Abstract
As carbapenems is the last line of defense for the treatment of life-threatening infections by drug-resistant Enterobacteriaceae, there is a major public health risk in the formation and dissemination of carbapenem-resistant Enterobacteriaceae, in particular Klebsiella pneumoniae.The resistance to carbapenem in Klebsiella pneumoniae was first discovered a decade ago and has since spread to many countries. Klebsiella pneumoniae carbapenemase (KPC), a community of carbapenem-resistant Klebsiella pneumoniae strains conferred by plasmid-encoded carbapenem enzymes, is rapidly spreading worldwide. In addition to KPC-producing Klebsiella pneumoniae several different metallo-b-lactamase-producing Klebsiella pneumoniae strains have been reported. These enzymes include New Delhi metallo-b-lactamase, Verona integrin-encoded metallo-b-lactamase, and imipenemases metallo-b-lactamase. Finally, has carbapenemases of class D, including carbapenemases of the oxacillin form. Carbapenem-resistant Klebsiella pneumoniae (CRKP) has been related to a high mortality rate and can cause pneumonia, bloodstream infections, meningitis, and urinary tract infections, among other infections. Hygienic handling, touch protocols, patients' and cohorting of staff must be part of a multifaceted approach to reducing CRKP nosocomial transmission, avoiding intrusive device use, encouraging antimicrobial stewardship, screening, aggressive monitoring and chlorhydrate bathing. In addition, immediate clinical infection notification after detection of CRKP in clinical specimens will allow control measures to be taken.
Keywords:
Carbapenem, Klebsiella pneumoniae ,drug-resistant