Seybold Report ISSN: 1533-9211
Anjali Sankar
Department of Conservative Dentistry and Endodontics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India, Mail Id : 152006006.sdc@saveetha.com
Sindhu Ramesh
Professor, Department of Conservative Dentistry and Endodontics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University,
Chennai, India, Mail Id :sindhuramesh@saveetha.com
Nishitha Arun
Department of Conservative Dentistry and Endodontics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University,
Chennai, India, Mail Id : 152006004.sdc@saveetha.com
Vol 17, No 09 ( 2022 ) | DOI: 10.5281/zenodo.7095086 | Licensing: CC 4.0 | Pg no:1183-1196 | Published on: 20-09-2022
Abstract
Introduction
The discovery of nanoparticles' unique properties has allowed them to be used in a variety of fields, including bioengineering.Chitosan is a linear polyaminosaccharide made from chitin, the second most prevalent natural biopolymer after cellulose. It can be readily produced into a number of forms that may be tailored to specific applications. The goal of this research was to synthesise chitosan nanoparticles with chlorhexidine and to characterise its properties using FTIR and SEM.
Materials and Methods
Synthesis and optimization of chitosan nanoparticles followed by Preparation of Nanochitosan with Chlorhexidine solution by adding 50ml of 2% Chlorhexidiene was added to 50 ml of the prepared nano chitosan solution. The resulting solution was sonicated for 10 mins until the solution was clear. The properties of the resultant solution were characterised by using FTIR and SEM.
Results
The chitosan nanoparticles prepared in the experiment exhibited white powder shape. The SEM micrographs of the nano chitosan with chlorhexidine showed that they were approximately circular and conical shaped nanoparticles of varying sizes. The unmodified chitosan nanoparticles are composed of clusters of nanoparticles with sizes ranging from 10 nm to 80 nm.
Conclusion
The results show that a novel chitosan nanoparticle was successfully synthesised and characterised. It seems that this nanoparticle like the other chitosan nanoparticles has potential applications as an irrigant having antimicrobial properties, increased depth of penetration into the dentinal tubules and removal of the smear layer in the field of endodontics.
Keywords:
Biomedical engineering, Chitosan, Chlorhexidine, Endodontics, Irrigant, Nanomedicine, Nanoparticle